Hemodialysis is just not routinely utilised to reinforce the elimination of codeine or promethazine from the body.
Promethazine HCl and Codeine Phosphate Oral Solution needs to be utilised with warning in patients with severe impairment of renal perform, and individuals need to be monitored closely for respiratory depression, sedation, and hypotension.
The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are elaborate, necessitating cautious thing to consider of the effects to the mum or dad drug, codeine, as well as the Energetic metabolite, morphine.
An increased danger of specific malformations with codeine exposure for instance respiratory malformations, spina bifida and congenital coronary heart defects were noted in a few studies.
Instances of adrenal insufficiency have already been noted with opioid use, a lot more typically subsequent increased than a person month of use. Instances of androgen deficiency have occurred with Continual usage of opioids [see
Amplified stress within your head (improved intracranial strain). Keep away from the use of Promethazine Hydrochloride and Codeine Phosphate Oral Solution For those who have a head injury or have already been told that you've got modifications inside the tissue within your brain (Mind lesions) or greater tension within your head.
Codeine may perhaps greatly enhance the neuromuscular blocking action of skeletal muscle mass relaxants and create a heightened diploma of respiratory despair.
Absorption Codeine is absorbed from the gastrointestinal tract with greatest plasma focus happening sixty minutes publish administration. The presence of a superior-Fats, substantial-calorie food didn't significantly impression the PK of codeine.
This medication may well comprise sugar and/or Alcoholic beverages. Warning is recommended Should you have diabetic issues, Liquor dependence, or liver condition. Inquire your physician or pharmacist about making use of this item safely.
Asthma and Other Pulmonary Disorder The use of Promethazine with Codeine Oral Solution in people with acute or critical bronchial asthma within an unmonitored setting or during the absence of resuscitative products is contraindicated [ see Contraindications ( four) ]. Opioid analgesics and antitussives, which check here includes codeine, on the list of Energetic substances in Promethazine with Codeine Oral Solution, shouldn't be Employed in individuals with acute febrile health issues linked with successful cough or in individuals with Long-term respiratory disease wherever interference with capacity to obvious the tracheobronchial tree of secretions might have a deleterious impact on the individual’s respiratory functionality.
Get hold of regional state Experienced licensing board or condition controlled substances authority for info on how to avoid and detect abuse or diversion of this product.
No proof of tumorigenicity was noticed in male and woman mice at codeine dietary doses approximately 400 mg/kg/day (approximately comparable to 45 situations the MRHD on a mg/m2 foundation).
Tend not to use this solution to treat chilly signs in little ones more youthful than 6 many years Except if precisely directed because of the medical professional. Some items (like extended-performing tablets/capsules) are not encouraged for use in young children young than 12 yrs. Inquire your doctor or pharmacist for more facts about using your merchandise safely.These products tend not to cure or shorten the duration on the popular cold and should trigger critical side effects. To lower the chance for major Unintended effects, cautiously comply with all dosage Instructions. Never use this product to produce a child sleepy. Usually do not give other cough-and-cold medication That may comprise the exact same or equivalent elements (see also Drug Interactions area). Check with the health care provider or pharmacist about other methods to relieve cough and cold signs and symptoms (including consuming ample fluids, utilizing a humidifier or saline nose drops/spray).
Daily life-threatening respiration issues (respiratory melancholy). PROMETHAZINE WITH CODEINE ORAL SOLUTION may cause respiration complications (respiratory despair) which will take place at any time during treatment and can cause Demise. Your possibility of breathing problems is biggest any time you initial start taking PROMETHAZINE WITH CODEINE ORAL SOLUTION, are getting other medicines that may cause respiratory troubles, have certain lung difficulties, are aged or have sure other health problems.